May 14, 2002Clinical Science

Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects

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Why the study?

Does intra-arterial BQ-123 alter forearm blood flow in response to ET-1 and noradrenaline in young normotensive subjects?

Population

n=6 young normotensive subjects, age 25-34 years

Comparison

Intra-arterial infusion of BQ-123 vs Intra-arterial infusion of sodium nitroprusside…

Design

RCT, randomized, double-blind

Follow-up

acute (during 60 min infusion)

Authors

RWR. WimalasunderaUniversity College Hospital STSimon ThomPreventive Cardiology LRL. ReganUniversity of London

Discussion

Member takes

Implication

ET_A blockade with BQ-123 spares basal tone yet abolishes ET-1 vasoconstriction in normotensives; confirms selective antagonism for targeted vascular research.

Structured PICO

Does intra-arterial BQ-123 alter forearm blood flow in response to ET-1 and noradrenaline in young normotensive subjects?

Population

n=6 young normotensive subjects, age 25-34 years

Intervention

Intra-arterial infusion of BQ-123 (50 nmol/min for 60 min, or 300 nmol/min for 5 min followed by saline for 55 min)

Comparator

Intra-arterial infusion of sodium nitroprusside (SNP; 12 nmol/min for 60 min) or saline

Outcome

Changes in forearm blood flow (FBF) in response to ET-1 and noradrenaline, measured by forearm occlusion plethysmographysurrogate

BQ-123 acts as a selective ET-1 antagonist but does not appear to significantly influence resting forearm vascular tone in young normotensive subjects.

Cite This Study

Wimalasundera et al. (2002) studied this question.

synapsesocial.com/papers/6a82f4bd28b8a62be998f808 https://doi.org/10.1042/cs1020661

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May 14, 2002Clinical Science

Action of the endothelin receptor (ETA) antagonist BQ-123 on forearm blood flow in young normotensive subjects

View Full Paper

Ask AI

Bookmark

Why the study?

Does intra-arterial BQ-123 alter forearm blood flow in response to ET-1 and noradrenaline in young normotensive subjects?

Population

n=6 young normotensive subjects, age 25-34 years

Comparison

Intra-arterial infusion of BQ-123 vs Intra-arterial infusion of sodium nitroprusside…

Design

RCT, randomized, double-blind

Follow-up

acute (during 60 min infusion)

Authors

RWR. WimalasunderaUniversity College Hospital STSimon ThomPreventive Cardiology LRL. ReganUniversity of London

Discussion

Member takes

Implication

ET_A blockade with BQ-123 spares basal tone yet abolishes ET-1 vasoconstriction in normotensives; confirms selective antagonism for targeted vascular research.

Structured PICO

Does intra-arterial BQ-123 alter forearm blood flow in response to ET-1 and noradrenaline in young normotensive subjects?

Population

n=6 young normotensive subjects, age 25-34 years

Intervention

Intra-arterial infusion of BQ-123 (50 nmol/min for 60 min, or 300 nmol/min for 5 min followed by saline for 55 min)

Comparator

Intra-arterial infusion of sodium nitroprusside (SNP; 12 nmol/min for 60 min) or saline

Outcome

Changes in forearm blood flow (FBF) in response to ET-1 and noradrenaline, measured by forearm occlusion plethysmographysurrogate

BQ-123 acts as a selective ET-1 antagonist but does not appear to significantly influence resting forearm vascular tone in young normotensive subjects.

Cite This Study

Wimalasundera et al. (2002) studied this question.

synapsesocial.com/papers/6a82f4bd28b8a62be998f808 https://doi.org/10.1042/cs1020661

Also Consider

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