Key result
Risk-adjusted in-hospital mortality for NSTEMI decreased significantly from 2002 to 2011 (adjusted OR per year 0.976; 95% CI 0.974-0.978), alongside increased use of early invasive strategy.
Why the study?
How have the incidence, utilization of early invasive strategy, and in-hospital outcomes for NSTEMI changed in the US from 2002 to 2011?
Population
3,981,119 patients ≥40 years of age with a principal diagnosis of NSTEMI from the 2002-2011 Nationwide…
Comparison
Early invasive strategy (EIS) at day 0 or day 0-1 vs Temporal trends (2002 vs 2011)
Design
Cohort
Follow-up
in-hospital
Authors
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NSTEMI mortality decline coincided with rising early invasive use; leaves open causal contribution versus secular trends in this observational cohort.
Observational (n=6,512,372)
Yes
How have the incidence, utilization of early invasive strategy, and in-hospital outcomes for NSTEMI changed in the US from 2002 to 2011?
Odds Ratio: 0.976 (95% CI 0.974–0.978)
Between 2002 and 2011 in the US, the proportion of AMIs presenting as NSTEMI increased, accompanied by greater utilization of early invasive strategies and decreased in-hospital mortality.
Khera et al. (2014) conducted an observational in Non-ST-elevation myocardial infarction (NSTEMI) (n=6,512,372). Calendar year vs. Previous years was evaluated on Risk-adjusted in-hospital mortality (OR 0.976, 95% CI 0.974-0.978). Risk-adjusted in-hospital mortality for NSTEMI decreased significantly from 2002 to 2011 (adjusted OR per year 0.976; 95% CI 0.974-0.978), alongside increased use of early invasive strategy.
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