Key result
Genomic features of coxsackievirus A6, including recombinations in the P2-P3 region and mutations at positions 168-170 of the 3D protein, correlated with herpangina and HFMD pathogenicities.
Specific genomic features, including recombinations in the P2-P3 region and mutations in the 3D protein, correlate with the differing pathogenicities of CVA6 in herpangina versus hand, foot and mouth disease.
No immediate clinical implications from this animal study; leaves open whether CVA6 genomic features drive human HFMD or herpangina severity.
Aim: To study the genomic factors of coxsackievirus A6 (CVA6) correlated with herpangina and hand, foot and mouth disease (HFMD). Materials & methods: Complete genome of CVA6 strains and HFMD causing enteroviruses were enrolled for genomic comparisons. Results: Recombinations in the nonstructural P2-P3 region appeared to correlate with HFMD causing pathogenicity. Among nonrecombinant CVA6 strains, a markedly nucleotide diversity in 3C-3UTR was observed between herpangina and HFMD causing CVA6. Synonymous mutations take an important role in the evolution of CVA6 3C-3UTR region, as limited amino acid variations were resulted from the high nucleotide diversity. Key amino acid mutations at positions 168–170 of 3D protein were correlated with the differences in viral pathogenicities. Conclusion: These findings provide insights into viral genomic features correlated with CVA6 pathogenicities.
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Hao et al. (2016) studied Herpangina and hand, foot and mouth disease (HFMD). Genomic features of coxsackievirus A6 (CVA6) was evaluated on Viral pathogenicities (herpangina vs HFMD). Genomic features of coxsackievirus A6, including recombinations in the P2-P3 region and mutations at positions 168-170 of the 3D protein, correlated with herpangina and HFMD pathogenicities.
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