Key result
Genomic analysis of Coxsackievirus A12 isolates from patients with HFMD and HA identified 11 nonsynonymous mutations, four of which were identical between the two clinical presentations.
Why the study?
Coxsackievirus A12 mainly causes hand-foot-mouth disease or herpangina, prompting analysis of the genomic characteristics and discrepancies between isolates causing each presentation in Southwest China.
Observational
Genomic analysis of CVA12 isolates from HFMD and HA patients in Southwest China identified four consistent nonsynonymous mutations that may affect viral virulence.
Aim: Coxsackievirus A12 (CVA12) mainly causes hand–foot–mouth disease (HFMD) or herpangina (HA). Thus, the genomic characteristics of CVA12 isolates from Southwest China, especially the discrepancy between CVA12-HFMD and CVA12-HA were analyzed. Patients & methods: The full-length genome sequences of CVA12-HFMD and CVA12-HA were obtained and phylogenetic, nucleotide mutation, amino acid substitution and recombinant analyses were performed. Results: All CVA12 were closest to the Netherlands (2013) and have possibly recombined in the capsid coding region (P1) with other HEV-A. In the coding region, 54 base mutation result in 11 nonsynonymous mutations and four of them were identical mutations between CVA12-HFMD and CVA12-HA. Conclusion: Whether the presence of four consistent nonsynonymous mutation sites affect the virulence of the CVA12 deserves further study.
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Rao et al. (2020) conducted an observational in Hand-foot-mouth disease (HFMD) or herpangina (HA). Coxsackievirus A12 (CVA12) isolates vs. CVA12-HFMD vs CVA12-HA was evaluated on Genomic characteristics including phylogenetic, nucleotide mutation, amino acid substitution and recombinant analyses. Genomic analysis of Coxsackievirus A12 isolates from patients with HFMD and HA identified 11 nonsynonymous mutations, four of which were identical between the two clinical presentations.
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