Key result
Intracardiac stroke impedance measured by CRT-D correlated significantly with stroke volume determined by echocardiography (mean correlation coefficient 0.797; p=0.007).
Why the study?
Intracardiac impedance measured by CRT-D software may monitor hemodynamics, but its relationship with echocardiographic hemodynamic parameters required investigation in a controlled setting.
Does intracardiac impedance measured by CRT-D correlate with echocardiographic stroke volume in patients with heart failure?
Population
68 patients with CRT-D indication, NYHA class II/III, LVEF 15%–35%, and QRS ≥150 ms
Comparison
Intracardiac stroke impedance vs echocardiographic aortic velocity time integral during overdrive pacing
Design
Multicenter study across 12 investigational sites
Authors
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Suggests existing CRT-D hardware may offer a readily available surrogate for hemodynamic monitoring; leaves open whether.
Observational (n=68)
Yes
Does intracardiac impedance measured by CRT-D correlate with echocardiographic stroke volume in patients with heart failure?
Effect estimate: rmean 0.797 (95% CI lower bound 0.709)
p-value: p=0.007
Intracardiac impedance measured by standard CRT-D systems correlates well with echocardiographic stroke volume, offering a readily available method for hemodynamic monitoring without additional hardware.
Delnoy et al. (2021) conducted an observational in Heart failure (n=68). Intracardiac impedance measurement vs. Echocardiography was evaluated on Mean intra-individual correlation coefficient (rmean) between stroke impedance and aortic velocity time integral > 0.65 (rmean 0.797, 95% CI lower bound 0.709, p=0.007). Intracardiac stroke impedance measured by CRT-D correlated significantly with stroke volume determined by echocardiography (mean correlation coefficient 0.797; p=0.007).
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