Key result
Finite-element simulation demonstrated that circumferential wall strain is much higher in the untethered than tethered region of the coronary vessel wall at physiological pressure.
Population
Finite-element model of the left anterior descending artery embedded into the myocardium
Comparison
Embedding the left anterior descending artery… vs Untethered versus tethered regions of the vessel…
Design
Preclinical
Authors
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Hypothesis-generating for strain-mediated coronary remodeling; no clinical implications without in vivo validation.
This finite-element study provides a mechanical basis for understanding local growth and remodeling of coronary vessels, showing that elevated wall strain in untethered regions may stimulate intimal hyperplasia.
Liu et al. (2007) studied Coronary vessel wall mechanics. Myocardial constraint vs. Absence of myocardial constraint (untethered region) was evaluated on Circumferential wall strain and deformation. Finite-element simulation demonstrated that circumferential wall strain is much higher in the untethered than tethered region of the coronary vessel wall at physiological pressure.
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