Why the study?
What are the late clinical outcomes and complications in patients who underwent aortic valve replacement with the Starr-Edwards prosthesis?
What are the late clinical outcomes and complications in patients who underwent aortic valve replacement with the Starr-Edwards prosthesis?
Aortic valve replacement with the Starr-Edwards prosthesis provides clinical improvement in most survivors, but is associated with late prosthesis-related mortality and complications such as aortic regurgitation and intravascular haemolysis.
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Early AVR survivors improved clinically yet faced prosthesis-related mortality and hemolysis; leaves open long-term durability questions for modern valves.
Details are presented concerning 59 patients who left hospital between January 1964 and January 1969 after aortic valve replacement with the Starr-Edwards prosthesis. Of the 14 late deaths, 7 are known to have been due to causes related to the prosthesis and 4 to other causes. The 45 surviving patients have nearly all shown clinical improvement and only 3 are unable to work as a result of some complication of the operation. Aortic regurgitation and its consequences appear to be the most significant factor leading to symptoms. In 11 of 16 patients with anaemia there was evidence of intravascular haemolysis. The long-term consequence of this complication is not known.
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Morgans et al. (1970) studied this question.
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