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November 1, 1970HeartOpen Access

Late results of aortic valve replacement with the Starr-Edwards prosthesis.

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Why the study?

What are the late clinical outcomes and complications in patients who underwent aortic valve replacement with the Starr-Edwards prosthesis?

Population

59 patients who left hospital between January 1964 and January 1969 after aortic valve replacement with the…

Design

Cohort

Authors

CMC M MorgansGuy's and St Thomas' NHS Foundation TrustDBD W BarrittNorthern General HospitalRBRonald BelseyMaine Medical Center

Discussion

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Overview

Early AVR survivors improved clinically yet faced prosthesis-related mortality and hemolysis; leaves open long-term durability questions for modern valves.

Key Points

  • To assess the late clinical results, survival, and complication rates in patients undergoing aortic valve replacement with the Starr-Edwards ball-valve prosthesis.
  • Followed 59 patients discharged from the hospital between January 1964 and January 1969 after aortic valve replacement with a Starr-Edwards prosthesis.
  • Evaluated clinical recovery, work capacity, late mortality, and haematological complications during follow-up.
  • Out of 14 late deaths, 7 were directly attributable to prosthetic valve complications and 4 to unrelated causes.
  • Among the 45 surviving patients, nearly all demonstrated marked clinical improvement, with only 3 unable to work due to operative complications.
  • Aortic regurgitation was the primary driver of persistent symptoms, and 11 of 16 anaemic patients exhibited evidence of intravascular haemolysis.

Structured PICO

What are the late clinical outcomes and complications in patients who underwent aortic valve replacement with the Starr-Edwards prosthesis?

P
Population
59 patients who left hospital between January 1964 and January 1969 after aortic valve replacement with the Starr-Edwards prosthesis
I
Intervention
Aortic valve replacement with the Starr-Edwards prosthesis
O
Outcome
Late survival and clinical improvementhard clinical

Aortic valve replacement with the Starr-Edwards prosthesis provides clinical improvement in most survivors, but is associated with late prosthesis-related mortality and complications such as aortic regurgitation and intravascular haemolysis.

Cite This Study

Morgans et al. (1970) studied this question.

synapsesocial.com/papers/6a83052d687d8bb80798fa35https://doi.org/10.1136/hrt.32.6.812
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Survival After Starr-Edwards Aortic Valve Replacement1971 · 77 citations
  2. 2Long-term Results in 1375 Patients Undergoing Valve Replacement with the Starr-Edwards Cloth-covered Steel Ball Prosthesis1977 · 52 citations
  3. 3Prediction of Late Results Following Valve Replacement in Aortic Valve Stenosis1987 · 24 citations
  4. 4Immediate and long-term results of aortic valve replacement with University of Cape Town aortic valve prosthesis1970 · 8 citations
  5. 5Thromboembolic Complications of Prosthetic Cardiac Valves1968 · 120 citations