Key result
In spontaneously hypertensive rats, aliskiren had minor and statistically insignificant effects on target organs, diuresis, and albuminuria compared to enalapril and valsartan.
Why the study?
Does aliskiren improve renal function and protect hypertension target organs compared to enalapril and valsartan in spontaneously hypertensive rats?
Does aliskiren improve renal function and protect hypertension target organs compared to enalapril and valsartan in spontaneously hypertensive rats?
In a spontaneously hypertensive rat model, aliskiren demonstrated inferior end-organ protection and renal function improvement compared to enalapril and valsartan.
Answers are grounded in this paper and cite their sources.
Rat model shows no aliskiren advantage; leaves open comparative efficacy versus ACEI/ARB in human hypertension.
Aim: Aliskiren is the first orally active renin inhibitor approved for treatment of essential hypertension. There are as yet no clinical data regarding the ability of aliskiren to prevent clinical end-points or reduce end-organ damage over and above the presumed effects of blood pressure reduction. The aim of this study was to find out if aliskiren has a potential to improve renal function and if it has a protective effect on hypertension target organs (kidney, heart and aorta). Materials and Methods: The study was conducted on 64 SHR rats (male and female), 20 weeks old, weighing from 250-300 g. Animals were divided into 4 groups and treated with aliskiren (100 mg/kg bw/24 h), enalapril (10 mg/kg bw/24 h) and valsartan (10 mg/kg bw/24 h). Effects of investigated drugs were evaluated by urinalysis and histopathological analysis. Results: Diuresis was significantly increased in the group of animals treated with enalapril and valsartan. Effect on diuresis with aliskiren was mild and statistically insignificant. No significant difference in urine pH between treated and control group of SHR rats was noted. Albuminuria was decreased in animals treated with enalapril and valsartan. Aliskiren after 28 days of treatment had a statistically insignificant effect on albuminuria in SHR rats. Only certain changes of wall thickness of arteries and arterioles were noted that led to improved perfusion and function of the kidneys more pronounced in rats treated with valsartan and enalapril. Effects of aliskiren on target organs were inferior compared to valsartan and enalapril. Conclusion: In SHR experimental model aliskiren has minor effects on hypertension target organs when compared to enalapril and valsaratan.
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Gjorgjievska et al. (2011) studied Hypertension (n=64). Aliskiren vs. Enalapril (10 mg/kg bw/24 h) and valsartan (10 mg/kg bw/24 h) was evaluated on Renal function (diuresis, albuminuria) and histopathological changes in target organs. In spontaneously hypertensive rats, aliskiren had minor and statistically insignificant effects on target organs, diuresis, and albuminuria compared to enalapril and valsartan.
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