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March 1, 2025BMJ OpenOpen Access

Changes in peripapillary microvasculature and retinal nerve fibre layer in diabetes and diabetic retinopathy using optical coherence tomographic angiography: a community-based, cross-sectional study

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Authors

JLJiahui LiuDKDan KangZXZhiyi Xu

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Overview

Cross-sectional study reveals progressive loss of peripapillary microvessels and retinal nerve fibres in diabetic retinopathy, highlighting noninvasive optical imaging for tracking disease.

Key Points

  • To evaluate changes in peripapillary retinal microvasculature and retinal nerve fibre layer thickness across varying stages of diabetic retinopathy using swept-source optical coherence tomographic angiography.
  • Community-based, cross-sectional study of 1325 ocular-treatment-naive participants (1115 without diabetic retinopathy and 210 with diabetic retinopathy) conducted in Guangzhou, China.
  • Swept-source optical coherence tomographic angiography measured peripapillary vessel density, vessel length density, vessel diameter index, and nerve fibre layer thickness across regions centred on the optic disc.
  • Linear regression models evaluated associations between microvascular metrics, nerve fibre layer thickness, and retinopathy severity stages.
  • Moderate and severe diabetic retinopathy exhibited progressive decreases in peripapillary ring vessel density (β = -0.72, 95% CI -1.31 to -0.14 and β = -1.79, 95% CI -2.81 to -0.77, respectively; both p<0.05), with corresponding reductions in vessel length density.
  • Inferior quadrant retinal nerve fibre layer thickness was significantly decreased in moderate (β = -4.56, 95% CI -8.97 to -0.15, p=0.043) and severe retinopathy (β = -10.12, 95% CI -18.29 to -1.95, p=0.015).
  • Peripapillary vessel density and vessel length density correlated linearly with average retinal nerve fibre layer thickness across the peripapillary ring and average area (all p<0.05).

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6a8307c4ff6798fd267d5a23https://doi.org/10.1136/bmjopen-2023-079572
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal changes in anatomic biomarkers on optical coherence tomography angiography in diabetic retinopathy2026
  2. 2Assessment of early macular and peripapillary diabetic vascular changes using optical coherence tomography angiography2025
  3. 3Assessment of retinal and choroidal structural and microvascular changes in early diabetic retinopathy using swept-source optical coherence tomography angiography2025 · 2 citations
  4. 4Peripapillary Retinal and Choroidal Vasculature in Patients with Diabetes of Different Durations without Clinical Diabetic Retinopathy2026 · 1 citations
  5. 5OCT Angiography-Derived Retinal Microvascular Changes in Diabetic and Non-Diabetic Eyes and Their Relationship to Disease Severity: A Cross-Sectional Study2026