Why the study?
Does prolonged exercise or sodium nicotinate infusion affect arterial-coronary sinus differences in plasma immunoreactive insulin concentration in healthy men?
Does prolonged exercise or sodium nicotinate infusion affect arterial-coronary sinus differences in plasma immunoreactive insulin concentration in healthy men?
The human myocardium releases immunoreactive insulin during prolonged exercise and sodium nicotinate infusion, particularly at low arterial insulin concentrations.
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Myocardial insulin release may occur during prolonged exercise at low arterial levels; hypothesis-generating for cardiac metabolic regulation.
Arterial‐coronary sinus differences in plasma immunoreaetive insulin concentration have been determined in 21 healthy men in the fasting state. Measurements were made both at rest and during prolonged exercise in all subjects and, in 9 of these, during an intravenous infusion of sodium nicotinate. Significant myocardial extraction of insulin could not be detected, but during prolonged exercise and also during the infusion of sodium nicotinate in resting subjects, net release of insulin from the myocardium took place. There was a positive linear relationship between arterial‐coronary sinus difference in insulin concentration and arterial insulin concentration. The most marked release of insulin from the heart occurred at the lowest arterial concentrations.
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Wahlqvist et al. (1972) studied this question.
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