Key result
Infusions of a fat emulsion and glucose in male volunteers led to higher arterial insulin immunoreactivities, which were associated with greater arterial coronary sinus differences in insulin.
Why the study?
Does infusion of glucose and fat emulsion affect the extraction of immunoreactive insulin across the coronary circulation in male volunteers?
Observational (n=12)
Does infusion of glucose and fat emulsion affect the extraction of immunoreactive insulin across the coronary circulation in male volunteers?
The human heart extracts immunoreactive insulin, a process that increases with higher arterial insulin levels and during prolonged exercise.
Answers are grounded in this paper and cite their sources.
May increase myocardial insulin extraction during hyperinsulinemia in volunteers; leaves open relevance to cardiac metabolism or disease.
The extraction of immunoreactive insulin by the human heart has been examined using the technique of coronary sinus catheterisation. The subjects were 12 male volunteers. During the study infusions of a fat emulsion and glucose were given in an effort to create a "steady fed state". The higher arterial insulin immunoreactivities which were observed during the infusions were associated with greater arterial coronary sinus differences in insulin immunoreactivity. The possibility of insulin degradation by the heart is discussed. During prolonged exercise the process of insulin removal by the heart appeared more active.
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Carlson et al. (1975) reported an observational. Infusions of a fat emulsion and glucose was evaluated on Arterial coronary sinus differences in insulin immunoreactivity. Infusions of a fat emulsion and glucose in male volunteers led to higher arterial insulin immunoreactivities, which were associated with greater arterial coronary sinus differences in insulin.
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