Key result
A substantial subgroup of women with PCOS have insulin sensitivity comparable to healthy controls when carefully matched for potential confounding factors.
This review highlights that insulin resistance may not be a universal feature of PCOS, especially in non-obese patients, emphasizing the need to account for confounding factors.
Questions routine assumption of insulin resistance in PCOS; hypothesis-generating and requires confirmation in rigorously matched prospective studies.
Insulin resistance is often considered a regular component of polycystic ovary syndrome (PCOS). Many interventional studies assume a state of insulin resistance in all patients. However, the evidence is based on small samples that are often insufficient to adjust for significant confounding factors. Moreover, several studies have not confirmed differences in insulin sensitivity between women with PCOS and healthy controls, especially in non-obese patients. This debate article provides an overview of the data published regarding the presence of abnormal or normal insulin sensitivity in PCOS. In conclusion, available data offer evidence that a substantial subgroup of women with PCOS have insulin sensitivity comparable with healthy controls if matched carefully for potential confounding factors.
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David Cibula (2004) conducted a review in Polycystic ovary syndrome (PCOS). Insulin resistance vs. Healthy controls was evaluated on Insulin sensitivity. A substantial subgroup of women with PCOS have insulin sensitivity comparable to healthy controls when carefully matched for potential confounding factors.
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