July 1, 2002Journal of Hypertension

Left ventricular remodelling impacts on coronary flow reserve in hypertensive patients: is there a vascular mechanism?

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Hypertension (n=55). Intervention: Concentric left ventricular remodelling vs. Absence of concentric remodelling or normotensive controls. Primary outcome: Coronary flow reserve.

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Key result

Concentric left ventricular remodelling was associated with the greatest reduction in coronary flow reserve among hypertensive patients with angina.

Why the study?

Does concentric left ventricular remodeling reduce coronary flow reserve in hypertensive patients?

Population

49 hypertensive patients with symptoms of angina and coronary stenosis <20%, and 6 age-matched normotensive…

Comparison

Concentric left ventricular remodeling vs Normal left ventricular geometry / normotensive…

Design

Editorial

Authors

GJGarry JenningsPreventive Cardiology RDRodney J. DilleyThe University of Western Australia

Discussion

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Implication

This editorial highlights that concentric left ventricular remodeling in hypertensive patients is independently associated with reduced coronary flow reserve, suggesting specific microvascular structural changes.

Structured PICO

Does concentric left ventricular remodeling reduce coronary flow reserve in hypertensive patients?

Population

49 hypertensive patients with angina and <20% stenosis, and 6 age-matched controls, evaluated for the impact of left ventricular geometry on coronary flow reserve.

Exposure

Concentric left ventricular remodeling (observational exposure)

Comparator

Normal left ventricular geometry / normotensive controls

Outcome

Coronary flow reserve (measured by argon gas chromatographic method with dipyridamole)surrogate

Limitations

Small number of subjects
Classification into categories of remodelling was not absolute
Patients referred for chest pain may not be typical of the general hypertensive population
No analysis of biopsy material performed
Classification into various categories of remodeling was not absolute
Patients referred for chest pain may be a heterogeneous group and not typical of the general hypertensive population
No analysis of biopsy material was performed to test structural alterations

Cite This Study

Jennings et al. (2002) conducted an editorial in Hypertension (n=55). Concentric left ventricular remodelling vs. Absence of concentric remodelling or normotensive controls was evaluated on Coronary flow reserve. Concentric left ventricular remodelling was associated with the greatest reduction in coronary flow reserve among hypertensive patients with angina.

synapsesocial.com/papers/6a830a15e1ce079453581e79 https://doi.org/10.1097/00004872-200207000-00013

Topics

Hypertension management

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Left ventricular remodelling impacts on coronary flow reserve in hypertensive patients: is there a vascular mechanism?

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Left ventricular remodelling impacts on coronary flow reserve in hypertensive patients: is there a vascular mechanism?

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider