Population
Rats with renal failure induced by partial nephrectomy
Comparison
Partial nephrectomy vs Sham-operated animals
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothesis-generating in rat renal failure; leaves open whether ET antagonism merits human proteinuria trials.
In a rat model of chronic renal failure, increased renal endothelin production correlates with proteinuria and elevated systolic blood pressure.
Brooks et al. (1991) studied this question.
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