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January 1, 2001Thrombosis and Haemostasis

Risk of Pregnancy-related Venous Thrombosis in Carriers of Severe Inherited Thrombophilia

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Key result

Homozygous factor V Leiden carriers had a significantly increased risk of pregnancy-related venous thrombosis compared to women with normal coagulation (15.8% vs 0.5%; RR 41.3, 95% CI 4.1-419.7).

Why the study?

Does severe inherited thrombophilia (homozygous factor V Leiden or double heterozygous mutations) increase the risk of pregnancy-related venous thrombosis?

Population

236 pregnant women, including 15 homozygous factor V Leiden, 39 double heterozygous, and 182 with normal…

Comparison

Homozygous factor V Leiden or double… vs Normal coagulation

Design

Cohort

Follow-up

Pregnancy and postpartum period

Authors

CLCristina LegnaniPBPaolo BucciarelliEGElvira Grandone

Discussion

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Member takes

Overview

May support individualized prophylaxis decisions in pregnancy; extends observational risk data but leaves open need for RCT confirmation.

Study Design

Type

Cohort (n=236)

Multicenter

Yes

Structured PICO

Does severe inherited thrombophilia (homozygous factor V Leiden or double heterozygous mutations) increase the risk of pregnancy-related venous thrombosis?

P
Population
236 women who were relatives of index patients with thrombosis, including carriers of severe inherited thrombophilia and those with normal coagulation, evaluated during pregnancy and postpartum.
E
Exposure
Homozygous factor V Leiden or double heterozygous factor V Leiden and prothrombin gene mutation (Exposure)
C
Comparator
Normal coagulation
O
Outcome
Pregnancy-related venous thrombosishard clinical

Main Result

Relative Risk: 41.3 (95% CI 4.1–419.7)

Absolute Event Rate: 15.8% vs 0.5%

Homozygous factor V Leiden and double heterozygous carriers have a significantly increased risk of venous thrombosis during pregnancy and postpartum, supporting the need for anticoagulant prophylaxis.

Cite This Study

Legnani et al. (2001) conducted a cohort in Pregnancy-related venous thrombosis (n=236). Homozygous factor V Leiden vs. Normal coagulation was evaluated on Pregnancy-related venous thrombosis (RR 41.3, 95% CI 4.1-419.7). Homozygous factor V Leiden carriers had a significantly increased risk of pregnancy-related venous thrombosis compared to women with normal coagulation (15.8% vs 0.5%; RR 41.3, 95% CI 4.1-419.7).

synapsesocial.com/papers/6a830bded7df55868faf85dahttps://doi.org/10.1055/s-0037-1616134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The risk of pregnancy‐related venous thromboembolism in women who are homozygous for factor V Leiden2001 · 81 citations
  2. 2Pregnancy-associated venous thromboembolism in combined heterozygous factor V Leiden and prothrombin G20210A mutations2005 · 13 citations
  3. 3Pregnancy‐associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone2003 · 32 citations
  4. 4Prothrombin and Factor V Mutations in Women With a History of Thrombosis During Pregnancy and the Puerperium2000 · 31 citations
  5. 5Risk factors for clinical manifestations in carriers of Factor V Leiden and prothrombin gene mutations2009 · 11 citations