Why the study?
What is the risk of pregnancy-related VTE in women homozygous for factor V Leiden with a symptomatic first-degree relative?
What is the risk of pregnancy-related VTE in women homozygous for factor V Leiden with a symptomatic first-degree relative?
Women homozygous for factor V Leiden with a symptomatic first-degree relative have a 17% risk of pregnancy-related VTE, indicating a potential need for post-partum anticoagulant prophylaxis.
May inform individualized counseling in this subgroup; leaves open whether prophylaxis improves outcomes in homozygous factor V Leiden carriers.
The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post-partum period. The absolute risk for pregnancy-related VTE in heterozygous women with the factor V Leiden mutation is approximately 2%, but studies on this risk for homozygous women show conflicting results. In a retrospective family study, we found that the risk of pregnancy-related VTE in women with a symptomatic first-degree relative was 17% per pregnancy (95%CI 4.7-37.4). Anticoagulant prophylaxis during the post-partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy.
No takes yet. Share an insight, caveat, or question.
Middeldorp et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: