Pathological findings of dialysis-fistula vessels in seven regular hemodialysis patients.

Yutaka Matsui; Ikuko Matsui; Eio Takahashi; Junko Amaki; T Tomokuni; Takahiko Yasuda; Tsuneo Tanioka; Tetsuya Imai; Takayuki Inoue

doi:10.4009/jsdt.30.257

January 1, 1997Nihon Toseki Igakkai ZasshiOpen Access

Pathological findings of dialysis-fistula vessels in seven regular hemodialysis patients.

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Key Points

To investigate the histopathological characteristics and lesion progression mechanisms of dialysis-fistula vessels at and distant from chronic puncture sites in maintenance hemodialysis patients.
Conducted histopathological evaluations of dialysis fistula vessels obtained from maintenance hemodialysis patients (N=7).
Stained tissue specimens using hematoxylin-eosin, Azan, Elastica van Gieson, Aldehyde-Fuchsin, and HE-von Kossa methods, alongside anti-α-actin immunohistochemistry.
Performed ACE genotype analysis across patient samples.
All examined fistula vessels exhibited arterialized venous changes with chronic thrombotic phlebitis, severe elastic lamina disruption, and eccentric intimal fibrous thickening without foam cells.
Immunohistochemistry demonstrated active migration and proliferation of α-actin-positive smooth muscle cells in thickened intima and lesion areas alongside persistent chronic panvasculitis.
Severe hemorrhagic adventititis with fibrous sclerosis was observed, and no patients carried the ACE DD genotype, suggesting adventitial inflammation and mechanical puncture trauma drive occlusive remodeling.

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Implication

Histopathological study reveals panvasculitis, smooth muscle proliferation, and adventititis in dialysis fistulas, indicating puncture trauma and widespread inflammation drive access failure.

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Matsui et al. (1997) studied this question.

synapsesocial.com/papers/6a830be495f6f1aefa9c8ae4 https://doi.org/10.4009/jsdt.30.257

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Pathological findings of dialysis-fistula vessels in seven regular hemodialysis patients.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Pathological findings of dialysis-fistula vessels in seven regular hemodialysis patients.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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