BNP and NT‒proBNP in Hemodialysis

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Maintenance hemodialysis (n=168). Intervention: Sacubitril valsartan vs. No sacubitril valsartan. Primary outcome: Correlation coefficient (r) between post-dialysis Log(NT-proBNP) and Log(BNP) (p=NS).

Ryoichi Miyazaki; Ayaka Kidani; Kyoko Miyagi; Kazuhiko Igarashi; Mitsuo Awaji; Reiko Kitagawa

doi:10.4009/jsdt.59.507

January 1, 2026Nihon Toseki Igakkai ZasshiOpen Access

BNP and NT‒proBNP in Hemodialysis

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Key Points

To examine how sacubitril/valsartan therapy and hemodialysis sessions affect BNP and NT-proBNP concentrations and their associations with echocardiographic parameters.
Measured post-dialysis BNP via chemiluminescent immunoassay and NT-proBNP via fluorescence immunoassay, assessing correlations with echocardiographic and electrocardiographic parameters.
Analyzed pre- and post-dialysis biomarker fluctuations and their relationship to intradialytic weight loss in a subset of 48 patients.
Log(NT-proBNP) strongly correlated with Log(BNP) in Group A (r=0.829, p=4.11×10⁻²⁰) and Group B (r=0.815, p=3.08×10⁻²³), with no significant difference between the regression slopes.
Multivariable analysis identified left ventricular mass index (LVMI) as the only parameter independently correlated with Log(NT-proBNP) (p=0.003).
Both NT-proBNP (p=1.68×10⁻⁹) and BNP (p=7.11×10⁻¹⁵) decreased significantly post-dialysis, but neither change correlated with weight loss percentage (NT-proBNP: r=0.133, p=0.366; BNP: r=0.0836, p=0.572).

Study Design

Type

Cross-Sectional (n=168)

Multicenter

No

PICO

P

Population

168 maintenance hemodialysis patients, including 93 treated with sacubitril valsartan for at least 3 months and 75 not treated, evaluated for the correlation between BNP and NT-proBNP levels.

E

Exposure / Comparator

Sacubitril valsartan vs No sacubitril valsartan

O

Primary Outcome

Correlation coefficient (r) between post-dialysis Log(NT-proBNP) and Log(BNP), p=NS

Main Result

Absolute Event Rate: 0.815% vs 0.829%

p-value: p=NS

Limitations

Single-center study
Cross-sectional design
Small sample size
Potential influence of assay variations in BNP and NT-proBNP measurements

Implication

Observational study finds strong BNP and NT-proBNP correlation irrespective of sacubitril/valsartan in hemodialysis patients, indicating both biomarkers reliably reflect left ventricular mass.

Abstract

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Cite This Study

Miyazaki et al. (2026) conducted a cross-sectional in Maintenance hemodialysis (n=168). Sacubitril valsartan vs. No sacubitril valsartan was evaluated on Correlation coefficient (r) between post-dialysis Log(NT-proBNP) and Log(BNP) (p=NS).

synapsesocial.com/papers/6abb06eb077501092874c06c https://doi.org/10.4009/jsdt.59.507

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BNP and NT‒proBNP in Hemodialysis

Key Points

Study Design

PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

BNP and NT‒proBNP in Hemodialysis

Key Points

Study Design

PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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