Key result
Trandolapril treatment reduced systemic blood pressure, proteinuria, and expression of TGF-beta1, endoglin, and collagens in rats with experimental renal fibrosis.
Why the study?
Does trandolapril reduce renal fibrosis via endoglin upregulation in rats with experimental renal fibrosis?
Population
Rats with experimental renal fibrosis induced by 5/6-nephrectomy renal mass reduction (RMR)
Comparison
Trandolapril (0.7 mg/kg/day) vs No treatment (RMR without trandolapril)
Design
Preclinical
Follow-up
1, 3 and 5 months
Authors
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Challenges endoglin upregulation hypothesis in rat fibrosis models; leaves open any clinical translation.
Does trandolapril reduce renal fibrosis via endoglin upregulation in rats with experimental renal fibrosis?
Trandolapril decreases renal fibrosis in a rat model of renal mass reduction, likely through reduced TGF-beta1 expression rather than increased endoglin expression.
Prieto et al. (2004) studied Experimental Renal Fibrosis. Trandolapril vs. Not treated was evaluated on Mean arterial pressure, renal function, renal fibrosis, and expression of endoglin, TGF-beta1, and collagens. Trandolapril treatment reduced systemic blood pressure, proteinuria, and expression of TGF-beta1, endoglin, and collagens in rats with experimental renal fibrosis.
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