Key result
Exposing human vascular smooth muscle cells to norepinephrine increased collagen protein production by 42% (P<0.01) compared to unstimulated control cells.
Effect estimate: 42% increase
p-value: p=<0.01
Alpha1- and beta1-adrenergic stimulation have opposing direct effects on extracellular matrix protein production and TGFbeta1 expression in human vascular smooth muscle cells.
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Hypothesis-generating for norepinephrine effects on vascular fibrosis; leaves open in vivo relevance of opposing alpha1/beta1 actions.
O’Callaghan et al. (2002) studied Cultured human vascular smooth muscle cells. Norepinephrine vs. Control (unstimulated) cells was evaluated on Collagen protein production (42% increase, p=<0.01). Exposing human vascular smooth muscle cells to norepinephrine increased collagen protein production by 42% (P<0.01) compared to unstimulated control cells.
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