Key result
Guanethidine increased collagen types I and III and decreased elastin, while losartan had an opposite effect, indicating that SNS and ANG II exert antagonistic effects on vascular ECM.
The sympathetic nervous system and angiotensin II exert opposite and antagonistic effects on major extracellular matrix components in the vascular wall, which may inform therapeutic strategies in vascular diseases.
Should not change clinical practice; leaves open whether SNS-ANG II antagonism on vascular ECM translates to humans.
The interactions between the effects of the sympathetic nervous system (SNS) and angiotensin II (ANG II) on vascular extracellular matrix (ECM) synthesis were determined in rats. The mRNA and protein content of collagen I, collagen III and elastin in the abdominal aorta (AA) and femoral artery (FA) was investigated in Wistar-Kyoto rats treated for 5 weeks with guanethidine, a sympathoplegic, losartan, an ANG II AT1 receptor (AT1R) blocker, or both. The effects of noradrenaline (NE) and ANG II on collagen III and elastin mRNA, and the receptor involved, were tested in cultured vascular smooth muscle cells (VSMCs) in vitro. Guanethidine increased collagen types I and III and decreased elastin, while losartan had an opposite effect, although without effect on collagen III. The combination of treatments abrogated changes induced by simple treatment with collagen I and elastin, but increased collagen III mRNA in AA and not in FA. NE stimulated collagen III mRNA via β receptors and elastin via α1 and α2 receptors. ANG II stimulated collagen III but inhibited elastin mRNA via AT1R. Overall, SNS and ANG II exert opposite and antagonistic effects on major components of ECM in the vascular wall. This may be of relevance for the choice of a therapeutic strategy in vascular diseases.
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Dab et al. (2011) studied this question. Guanethidine, losartan, or both was evaluated on mRNA and protein content of collagen I, collagen III and elastin in the abdominal aorta and femoral artery. Guanethidine increased collagen types I and III and decreased elastin, while losartan had an opposite effect, indicating that SNS and ANG II exert antagonistic effects on vascular ECM.
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