January 1, 2007Sunhwan'gi
Characteristics of Transplant Coronary Artery Disease after Heart Transplantation in Koreans: A Serial Intravascular UltraSound Analysis
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Key result
In Korean heart transplant recipients, the incidence of de novo coronary lesions in the first year was 14%, with a negative coronary arterial remodeling pattern in the early period that became positive during the late period.
Population
101 consecutive Korean patients who underwent heart transplantation and were examined via serial…
Design
Cohort
Follow-up
mean 21.6 months to follow-up IVUS
Authors
Discussion
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Implication
Does not warrant changes to post-transplant surveillance; leaves open the prognostic value of remodeling shifts in broader populations.
Study Design
Type
Observational (n=101)
Multicenter
No
Structured PICO
P
Population
101 heart transplant recipients (mean age 40.1 years, 18% female) who underwent serial intravascular ultrasound and coronary angiography to evaluate transplant coronary artery disease.
E
Exposure
Serial intravascular ultrasound (IVUS) evaluation (early period group evaluated within 1st month and at 1 year; late period group evaluated after 1 year and over another 1 year interval)
O
Outcome
Incidence and characteristics of significant transplant coronary artery disease (CAD) and coronary arterial remodeling patternsurrogate
Main Result
Absolute Event Rate: -1.85% vs -0.16%
p-value: p=0.001
In Korean heart transplant recipients, the incidence of significant transplant coronary artery disease is relatively low, characterized by negative arterial remodeling in the early post-transplant period that shifts to positive remodeling later.
Limitations
- The serial IVUS follow up period was different between groups, making direct comparison between early and late phases potentially unsuitable.
- The serial IVUS follow-up period was different between groups, making comparison between early and late phases potentially unsuitable.
Cite This Study
Park et al. (2007) conducted an observational in Transplant coronary artery disease (n=101). Post-transplant early period vs. Post-transplant late period was evaluated on Change in lumen area (mm2) (p=0.001). In Korean heart transplant recipients, the incidence of de novo coronary lesions in the first year was 14%, with a negative coronary arterial remodeling pattern in the early period that became positive during the late period.
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