Key result
Serial OCT evaluation during the first year after heart transplantation revealed a 20% increase in mean intima area (1.6 to 1.9 mm2, p<0.0001) and a 5-fold increase in layered fibrotic plaques.
Why the study?
Does serial optical coherence tomography detect early changes in coronary artery microstructure during the first year after heart transplantation?
Population
26 patients evaluated at routine baseline coronary angiography 3 months after heart transplantation (HTx)
Comparison
Serial optical coherence tomography scans of all… vs Baseline OCT scans at 3 months post-HTx
Design
Cohort
Follow-up
12 months post-HTx
Authors
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Serial OCT may detect early allograft vasculopathy progression; hypothesis-generating for surveillance utility and outcome prediction.
Observational (n=26)
Does serial optical coherence tomography detect early changes in coronary artery microstructure during the first year after heart transplantation?
Absolute Event Rate: 1.9% vs 1.6%
p-value: p=<0.0001
Serial OCT reveals that early cardiac allograft vasculopathy is characterized by pronounced intima thickening and layered fibrotic plaque progression within the first year post-transplant.
Clemmensen et al. (2017) conducted an observational in Heart transplantation (n=26). Time post-heart transplantation (12 months) vs. 3 months post-heart transplantation was evaluated on Mean intima area (p=<0.0001). Serial OCT evaluation during the first year after heart transplantation revealed a 20% increase in mean intima area (1.6 to 1.9 mm2, p<0.0001) and a 5-fold increase in layered fibrotic plaques.
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