May 1, 1991Journal of VirologyOpen Access

The 5'-terminal nucleotides of hepatitis A virus RNA, but not poliovirus RNA, are required for infectivity

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Population

Cultured BS-C-1 cells

Comparison

Transfection with hepatitis A virus RNA… vs Transfection with poliovirus RNA transcripts…

Design

Preclinical

Authors

Discussion

Does not alter HAV management; leaves open species-specific 5' RNA requirements for future antiviral exploration.

Population

Cultured BS-C-1 cells

Intervention

Transfection with hepatitis A virus (HAV) RNA transcripts differing in the number of 5'-terminal nucleotides

Comparator

Transfection with poliovirus RNA transcripts lacking the first two uridylate residues

Outcome

Infectivity (initiation of an infectious cycle leading to production of progeny virus)surrogate

The 5'-terminal nucleotides of hepatitis A virus RNA are essential for infectivity, unlike those of poliovirus RNA.

Harmon et al. (1991) studied this question.

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