Key result
Non-invasive hemodynamic indicators independently predicted 6-month MACE in 242 STEMI patients and significantly improved the predictive ability of the GRACE score.
Why the study?
To evaluate the correlation between non-invasive cardiac function monitoring indexes and recent adverse prognosis in STEMI patients, and assess whether combining them with GRACE score improves risk prediction.
Does combining non-invasive cardiac function monitoring indexes with the GRACE score improve the prediction of 6-month MACE in patients with STEMI?
Cohort (n=242)
Does combining non-invasive cardiac function monitoring indexes with the GRACE score improve the prediction of 6-month MACE in patients with STEMI?
Combining non-invasive hemodynamic indicators like stroke volume and cardiac time intervals with the GRACE score improves short-term MACE prediction in STEMI patients.
May enhance short-term MACE prediction in STEMI when added to GRACE; hypothesis-generating and requires prospective validation.
OBJECTIVE: To investigate the correlation between non-invasive cardiac function monitoring indexes and recent adverse prognosis in patients with STEMI. The hemodynamic indexes with high diagnostic value were selected to construct a new risk prediction model combined with GRACE scores, and the efficiency of the new prediction model was evaluated. METHODS: STEMI patients who met the inclusion and exclusion criteria were selected. All patients were followed for 6 months of major adverse cardiovascular events (MACE). The non-invasive cardiac function monitoring indexes were analyzed by univariate and multivariate logistic regression. The ROC curve was used to evaluate the accuracy of non-invasive cardiac function indexes predicting MACE. Then, a new risk prediction model was established and its prediction efficiency was evaluated by ROC curve. RESULTS: Patients were divided into MACE group (N = 69) and non-MACE group (N = 173), stroke volume (SV), cardiac output (CO), cardiac index (CI), cardiac time intervals (CTI), early diastolic filling rate (EDFR), end-diastolic volume (EDV), and systemic vascular resistance (SVR) were found to be significant predictors of recent MACE events in STEMI patients. Multivariate logistic regression analysis confirmed that indicators of noninvasive cardiac function were independent predictors. In addition, the combination of SV and CTI with the GRACE score has the potential to enhance the predictive accuracy for MACE. CONCLUSION: Non-invasive hemodynamic indicators SV, CO, CI, CTI, EDFR, EDV and SVR can not only independently predict the risk of recent MACE in patients with STEMI, but can also be used as joint indicators to significantly improve the predictive ability of GRACE score.
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Xin et al. (2025) conducted a cohort in ST-Segment Elevation Myocardial Infarction (STEMI) (n=242). Non-invasive cardiac function monitoring indexes combined with GRACE score vs. GRACE score alone was evaluated on Major adverse cardiovascular events (MACE). Non-invasive hemodynamic indicators independently predicted 6-month MACE in 242 STEMI patients and significantly improved the predictive ability of the GRACE score.
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