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November 23, 2021International Journal of CardiologyOpen Access

Novel 8-point clinical-CMR score stratifies early post-STEMI MACE risk, revealing a ~10-fold difference between risk extremes.

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Why the study?

CMR performed early after STEMI can improve MACE risk prediction, prompting the development of a simple clinical-CMR risk score for early risk stratification.

Does a combined clinical-CMR risk score predict MACE in reperfused STEMI patients?

Population

1118 reperfused STEMI patients

Design

Multicenter prospective registry

Follow-up

Median 5.52 [2.63-7.44] years

Key result

A novel 8-point clinical-CMR risk score stratified MACE risk early after STEMI, with rates of 1.96, 5.44, and 19.7 per 100 person-years in low, intermediate, and high-risk categories (p<0.001).

Authors

VMVíctor Marcos‐GarcésNPN PérezJGJosé Gavara

Discussion

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Member takes

Overview

May aid post-STEMI risk stratification; hypothesis-generating pending prospective validation.

Study Design

Type

Cohort (n=1,118)

Multicenter

Yes

Structured PICO

Does a combined clinical-CMR risk score predict MACE in reperfused STEMI patients?

P
Population
1118 reperfused STEMI patients, mean age 59.3 ± 12.3 years, 82.8% male.
I
Intervention
Clinical-CMR risk score (time to reperfusion >4.15 h, GRACE risk score > 155, CMR-LVEF <40%, and MVO >1.5 segments)
O
Outcome
MACE (combined clinical endpoint of cardiovascular death, non-fatal myocardial infarction, or re-admission for acute decompensated heart failure)composite

Main Result

p-value: p=< 0.001

A novel 8-point risk score combining clinical and CMR variables effectively stratifies long-term MACE risk in patients early after reperfused STEMI.

Limitations

  • Requires external validation to confirm applicability
  • Lack of external validation

Cite This Study

Marcos‐Garcés et al. (2021) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=1,118). Clinical-CMR risk score was evaluated on Major adverse cardiac events (cardiovascular death, non-fatal myocardial infarction, or re-admission for acute decompensated heart failure) (p=< 0.001). A novel 8-point clinical-CMR risk score stratified MACE risk early after STEMI, with rates of 1.96, 5.44, and 19.7 per 100 person-years in low, intermediate, and high-risk categories (p<0.001).

synapsesocial.com/papers/6a169f5df96f07bf256b3f83https://doi.org/10.1016/j.ijcard.2021.11.050
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Also Consider

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