Why the study?
Does virally mediated delivery of ACE antisense cDNA reduce ACE expression and blood pressure in spontaneously hypertensive rats?
Population
Rat pulmonary artery endothelial cells (RPAECs) and spontaneously hypertensive rats
Comparison
Retroviral vectors containing ACE antisense… vs Retroviral vectors containing ACE sense sequences
Design
Preclinical
Authors
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ACE-AS lowers BP in hypertensive rats; leaves open translation of this gene therapy approach to human hypertension.
Does virally mediated delivery of ACE antisense cDNA reduce ACE expression and blood pressure in spontaneously hypertensive rats?
Virally mediated delivery of ACE antisense cDNA provides sustained inhibition of ACE expression and long-term reduction in blood pressure in spontaneously hypertensive rats, suggesting a potential gene therapy approach for hypertension.
Wang et al. (1999) studied this question.
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