Why the study?
Does central infusion of angiotensin modulate the baroreceptor reflex in anesthetized dogs?
Does central infusion of angiotensin modulate the baroreceptor reflex in anesthetized dogs?
Central infusion of angiotensin suppresses the tonic inhibition of the baroreceptor reflex, suggesting it sensitizes the medullary vasomotor center to increase sympathetic outflow.
Central angiotensin may blunt baroreflex responses in dogs; leaves open its role in human sympathetic dysregulation.
A small amount of angiotensin not to cause a significant elevation of systemic arterial pressure was infused into vertebral arteries of dogs anesthetized with morphine and α-chloralose. Electrical stimulation of carotid sinus nerve caused a smaller reduction in arterial pressure and heart rate during the period of angiotensin infusion than the control period. Arterial pressure response to occlusion of the common carotid artery was not affected by the infusion of angiotensin. The results suggest that angiotensin may sensitize medullary vasomotor centre in a manner of suppressing the tonic inhibition of baroreceptor reflex, resulting in an increase of central sympathetic vasomotor outflow.
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Koshiro Fukiyama (1973) studied this question.
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