Key result
In vivo administration of isoprenaline predisposed IKs channel transgenic mice, but not wild-type littermates, to prolonged atrial arrhythmias.
Why the study?
Does beta-adrenergic stimulation of IKs channels induce atrial arrhythmias in a transgenic mouse model?
Does beta-adrenergic stimulation of IKs channels induce atrial arrhythmias in a transgenic mouse model?
Beta-adrenergic regulation of IKs channels can contribute to atrial fibrillation, suggesting that targeting the IKs macromolecular complex may be a novel therapeutic strategy.
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Isoprenaline-induced atrial arrhythmias in IKs transgenic mice suggest beta-adrenergic involvement; leaves open whether targeting this complex prevents human AF.
Sampson et al. (2007) studied Atrial fibrillation. Isoprenaline (isoproterenol) vs. Wild-type (WT) littermates was evaluated on Prolonged atrial arrhythmias. In vivo administration of isoprenaline predisposed IKs channel transgenic mice, but not wild-type littermates, to prolonged atrial arrhythmias.
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