Key Points
- To assess the relationship between estimated glomerular filtration rate and mean platelet volume in patients with stable coronary artery disease and normal to mildly impaired renal function.
- Cross-sectional analysis of 471 patients (288 males, 183 females; mean age 62.5±9.5 years) with angiographically proven stable coronary artery disease.
- Stratified patients into low (<60 ml/min/1.73 m²) and high (≥60 ml/min/1.73 m²) renal function groups using Cockcroft-Gault estimated glomerular filtration rate.
- Assessed coronary complexity via SYNTAX score and measured biomarkers including high-sensitive C-reactive protein and mean platelet volume using multivariate linear regression.
- Patients with eGFR <60 ml/min/1.73 m² were older, had higher rates of diabetes and hypertension, and exhibited higher SYNTAX scores, hs-CRP, and mean platelet volume compared to those with eGFR ≥60 ml/min/1.73 m².
- Multivariate linear regression demonstrated that mean platelet volume was independently negatively associated with eGFR (β = -0.267, p < 0.001) and platelet count (β = -0.116, p = 0.002).
- Diabetes (β = 0.189, p < 0.001) and hs-CRP level (β = 0.158, p < 0.001) were also identified as independent positive predictors of mean platelet volume.
Structured PICO
Is mean platelet volume associated with renal dysfunction in patients with stable coronary artery disease?
PPopulation471 patients (288 males and 183 females; mean age: 62.5±9.5 years) with angiographically proven stable coronary artery disease showing normal to mildly impaired renal function.
CComparatorPatients with estimated GFR ≥ 60 ml/min per 1.73 m² (GFRhigh group)
OOutcomeAssociation between estimated GFR and mean platelet volume (MPV)surrogate
Mean platelet volume is independently associated with declining glomerular filtration rate in patients with stable coronary artery disease, potentially explaining the increased atherothrombotic risk in mild renal impairment.