January 1, 1952The Journal of Experimental MedicineOpen Access

The Growth Curve of the Lansing Strain of Poliomyelitis Virus in Mice: The Effect of Sodium Monofluoroacetate and Methionine Sulfoximine on the Early Phase of Growth of the Virus

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Population

Mice inoculated intracerebrally with the Lansing strain of poliomyelitis virus

Design

Preclinical

Authors

JAJohn D. AinslieUniversity of Michigan

Discussion

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Implication

May inform metabolic antiviral strategies; leaves open translation to human poliomyelitis.

Structured PICO

Population

Mice inoculated intracerebrally with the Lansing strain of poliomyelitis virus

Intervention

Intraperitoneal administration of sodium monofluoroacetate (6 mg/kg or 3 mg/kg) or DL-methionine sulfoximine (150 mg/kg or 75 mg/kg) 1 hour before virus inoculation

Outcome

Early phase of growth of the virus in the mouse brain and cord, and time to first signs of illnesssurrogate

Sodium monofluoroacetate and methionine sulfoximine delay the early growth phase of poliomyelitis virus in mice, suggesting a link between cellular metabolism and viral synthesis.

Cite This Study

John D. Ainslie (1952) studied this question.

synapsesocial.com/papers/6a8327c09080d9133c4cdd47 https://doi.org/10.1084/jem.95.1.9

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The Growth Curve of the Lansing Strain of Poliomyelitis Virus in Mice: The Effect of Sodium Monofluoroacetate and Methionine Sulfoximine on the Early Phase of Growth of the Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Growth Curve of the Lansing Strain of Poliomyelitis Virus in Mice: The Effect of Sodium Monofluoroacetate and Methionine Sulfoximine on the Early Phase of Growth of the Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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