Why the study?
Does vitamin B1 deficiency or restricted food intake improve resistance to the Lansing strain of poliomyelitis virus in mice?
Population
Mice injected intracerebrally with a suspension of the Lansing strain of poliomyelitis virus
Comparison
Vitamin B1 deficient diet, restricted food… vs Normally fed control mice
Design
Preclinical
Follow-up
at least 12 days
Authors
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Animal findings on B1 deficiency and viral resistance in mice leave open any clinical relevance for human poliomyelitis.
Does vitamin B1 deficiency or restricted food intake improve resistance to the Lansing strain of poliomyelitis virus in mice?
In a mouse model, vitamin B1 deficiency and restricted food intake delayed the action of the poliomyelitis virus and reduced mortality and paralysis.
Foster et al. (1944) studied this question.
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