Population
In vitro model using Moloney murine leukemia virus (MoMuLV) NCp10 protein and viral RNA
Comparison
Modification or replacement of residues involved… vs Wild-type NCp10 protein
Design
Preclinical
Authors
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Zinc-independent NCp10 function redirects focus to lysine residues; extends retroviral models but leaves open human therapeutic relevance.
The viral RNA annealing and binding activities of the MoMuLV nucleocapsid protein are independent of zinc coordination, but depend on conserved lysine residues adjacent to the zinc finger motif.
Prats et al. (1991) studied this question.
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