Why the study?
Does muscle contraction and stretch increase sympathetic nerve activity more in rats with ischemic heart failure compared to controls?
Does muscle contraction and stretch increase sympathetic nerve activity more in rats with ischemic heart failure compared to controls?
In a rat model of ischemic heart failure, sympathetic nerve responses to muscle contraction and stretch are exaggerated, suggesting muscle afferent-mediated sympathetic outflows contribute to abnormal peripheral blood flow regulation during exercise.
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Exaggerated sympathetic responses to muscle contraction in MI rats may underlie exercise intolerance; leaves open translation to human HF hemodynamics.
Koba et al. (2007) studied this question.
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