Why the study?
Does intense activation of central command elicit exaggerated sympathetic responses in rats with myocardial infarction compared to controls?
Population
Decerebrated rats with myocardial infarctions and control rats
Comparison
30 s of fictive locomotion induced by electrical… vs Control rats receiving the same stimulation
Design
Preclinical
Authors
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May underlie excessive exercise vasoconstriction in HF; hypothesis-generating in rodent MI model, human validation needed.
Does intense activation of central command elicit exaggerated sympathetic responses in rats with myocardial infarction compared to controls?
Intense activation of central command elicits exaggerated sympathetic nerve responses in rats with myocardial infarction, suggesting a mechanism for excessive peripheral vasoconstriction during exercise in heart failure.
Koba et al. (2006) studied this question.
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