Key result
Electrical stimulation of the mesencephalic locomotor region evoked significantly greater increases in sympathetic activity (287% vs 153%) and blood pressure (139 vs 87 mmHg) in hypertensive rats.
Why the study?
Does electrical stimulation of the mesencephalic locomotor region cause exaggerated sympathetic and pressor responses in spontaneously hypertensive rats compared to normotensive rats?
Population
Decerebrate, paralyzed normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Electrical stimulation of the mesencephalic… vs Normotensive Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
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Central command may drive exaggerated sympathetic and pressor responses in hypertension; hypothesis-generating in rats, human translation untested.
Does electrical stimulation of the mesencephalic locomotor region cause exaggerated sympathetic and pressor responses in spontaneously hypertensive rats compared to normotensive rats?
Central command may be a critical contributor to the exaggerated rise in sympathetic activity and blood pressure during exercise in hypertension.
Liang et al. (2016) studied Hypertension. Electrical stimulation of mesencephalic locomotor region (MLR) vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Changes in renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP). Electrical stimulation of the mesencephalic locomotor region evoked significantly greater increases in sympathetic activity (287% vs 153%) and blood pressure (139 vs 87 mmHg) in hypertensive rats.
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