Why the study?
Whether the interactive relationship between central command and the exercise pressor reflex is altered in hypertension, contributing to an exaggerated pressor response during exercise, remains unknown.
Does concurrent stimulation of the MLR and SN alter the pressor response compared to individual stimulation in normotensive and hypertensive rats?
Population
Decerebrated, paralyzed normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats
Comparison
Individual vs concurrent electrical stimulation of the mesencephalic locomotor region and sciatic nerve
Design
Animal experimental study
Authors
Loading...
Attenuated CC-EPR occlusion in hypertensive rats may potentiate exercise pressor responses; leaves open relevance to human hypertension.
Does concurrent stimulation of the MLR and SN alter the pressor response compared to individual stimulation in normotensive and hypertensive rats?
The neural occlusion between central command and peripheral pressor mechanisms is attenuated in hypertension, which may contribute to the exaggerated blood pressure response to exercise.
Liang et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: