Why the study?
Does acute salt loading alter spontaneous baroreflex sensitivity in patients with resistant hypertension compared to healthy controls?
Does acute salt loading alter spontaneous baroreflex sensitivity in patients with resistant hypertension compared to healthy controls?
Spontaneous baroreflex sensitivity is reduced in resistant hypertension and further impaired during acute salt loading, correlating with blood pressure elevation and salt sensitivity.
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Baroreflex impairment may underlie salt sensitivity in RH; leaves open whether BRS-targeted interventions improve outcomes.
Objective. To assess spontaneous baroreflex sensitivity (BRS) in patients with resistant hypertension (RH) and changes during acute salt loading according to changes of blood pressure (BP). Design and methods. Thirty four patients with RH were included. Patients were on standard antihypertensive medication: lisinopril 20 mg per day, amlodipine 10 mg per day and hydrochlorothiazide 25 mg per day. Control group consisted of 11 age- and sex-matched healthy subjects. Salt loading test was performed with i.v. saline infusion (100 ml during 1 hour). Beat-to-beat BP was registered by Finometer Pro device and BRS was assessed by slope method. Results. BRS is reduced in RH patients both at baseline and after salt loading. The level of BP elevation during salt loading is related to BRS reduction, and both parameters are related to salt-sensitivity.
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Emelyanov et al. (2012) studied this question.
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