Why the study?
Does a high salt diet increase blood pressure in rabbits with low baroreflex sensitivity?
Population
27 normotensive rabbits of the second and third generation bred for differences in cardiac baroreflex…
Comparison
High salt diet (32 meq/day) for 3 weeks vs Normal NaCl diet (8 meq/day) for 3 weeks
Design
Preclinical
Follow-up
6 weeks (3 weeks normal salt, 3 weeks high salt)
Authors
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Low BRS may confer salt sensitivity in this rabbit model; leaves open any role in human hypertension.
Does a high salt diet increase blood pressure in rabbits with low baroreflex sensitivity?
Low baroreflex sensitivity predisposes rabbits to salt-sensitive hypertension, suggesting a mechanistic link between baroreflex function and blood pressure response to dietary salt.
Weinstock et al. (1993) studied this question.
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