Why the study?
Does bilateral renal denervation alter the hemodynamic and natriuretic responses to saline infusion in rabbits with impaired baroreflex sensitivity?
Population
Conscious male rabbits with either high or low cardiac baroreflex sensitivity
Comparison
Bilateral renal denervation vs Before renal denervation (intact state)
Design
Preclinical
Follow-up
11-14 days
Authors
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Supports sympathetic mediation of hemodynamics in baroreflex-impaired models; leaves open natriuretic mechanisms and human translation.
Does bilateral renal denervation alter the hemodynamic and natriuretic responses to saline infusion in rabbits with impaired baroreflex sensitivity?
In rabbits with impaired baroreflex sensitivity, the inability to increase renal plasma flow in response to saline is mediated by renal sympathetic nerves, whereas differences in natriuresis involve additional mechanisms.
Maybaum et al. (1998) studied this question.
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