August 1, 1993Journal of Hypertension

Rabbits with a genetic impairment in baroreceptor reflex sensitivity show abnormal renal haemodynamics and proximal tubular sodium reabsorption in response to a saline infusion

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Population

20 normotensive male rabbits bred for genetic differences in cardiac baroreflex sensitivity, divided into…

Comparison

Acute intravenous saline infusion following a… vs Comparison between the high BRS and low BRS…

Design

Preclinical

Follow-up

2 hours

Authors

MRMichal RazinHarvard University MBMichal BoroshHebrew University of Jerusalem MWMarta WeinstockIsrael Institute for Biological Research

Discussion

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Implication

Impaired baroreflex sensitivity may blunt renal salt responses in rabbits; leaves open a mechanistic role in human salt-sensitive hypertension.

Structured PICO

Population

20 normotensive male rabbits bred for genetic differences in cardiac baroreflex sensitivity (BRS), divided into high BRS (> 5 beats/min per mmHg, n=10) and low BRS (< 4 beats/min per mmHg, n=10) groups.

Intervention

Acute intravenous saline infusion (threefold increase in NaCl for 2 hours) following a control infusion of glucose and NaCl.

Comparator

Comparison between the high BRS (Group I) and low BRS (Group II) genetic groups in response to the same saline infusion.

Outcome

Effective renal plasma flow (ERPF) and proximal tubular sodium reabsorption (PTSR) measured by lithium clearance.surrogate

A genetic impairment in baroreflex sensitivity in rabbits prevents the normal increase in renal plasma flow and suppression of proximal tubular sodium reabsorption in response to salt loading, suggesting a mechanism for salt-sensitive hypertension.

Cite This Study

Razin et al. (1993) studied this question.

synapsesocial.com/papers/6a8a7aa9af6b08ee8d7239cf https://doi.org/10.1097/00004872-199308000-00006

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Implication

Impaired baroreflex sensitivity may blunt renal salt responses in rabbits; leaves open a mechanistic role in human salt-sensitive hypertension.

Rabbits with a genetic impairment in baroreceptor reflex sensitivity show abnormal renal haemodynamics and proximal tubular sodium reabsorption in response to a saline infusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rabbits with a genetic impairment in baroreceptor reflex sensitivity show abnormal renal haemodynamics and proximal tubular sodium reabsorption in response to a saline infusion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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