December 1, 1998Clinical Science

Relationship between arterial baroreflex, cardiopulmonary vagal reflex and renal natriuretic response to saline in conscious rabbits

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Population

Conscious normotensive rabbits varying widely in their arterial baroreflex sensitivity

Design

Preclinical

Follow-up

60-90 minutes after start of saline infusion

Authors

NMNadine MaybaumHadassah Medical Center EGElena GorodetskyNational Institutes of Health MWMarta WeinstockIsrael Institute for Biological Research

Discussion

Member takes

Implication

Baroreflex-renal salt links in rabbits are hypothesis-generating; leaves open translation to human salt-sensitive hypertension.

Structured PICO

Population

Conscious normotensive rabbits varying widely in their arterial baroreflex sensitivity

Intervention

Phenylbiguanide (to assess cardiopulmonary baroreceptor sensitivity) and mild saline infusion (0.11 ml.min-1.kg-1 into the ear vein)

Outcome

Correlation between cardiac arterial baroreflex gain, cardiopulmonary baroreceptor sensitivity, and renal blood flow/lithium clearance in response to salinesurrogate

In normotensive rabbits, reduced sensitivity of cardiopulmonary and arterial baroreceptors correlates with abnormal renal hemodynamic and natriuretic responses to salt.

Cite This Study

Maybaum et al. (1998) studied this question.

synapsesocial.com/papers/6a83b9f06eaad3b729ee7eaf https://doi.org/10.1042/cs0950693

Topics

Hypertension management

View Full Paper

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Bookmark

Relationship between arterial baroreflex, cardiopulmonary vagal reflex and renal natriuretic response to saline in conscious rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Relationship between arterial baroreflex, cardiopulmonary vagal reflex and renal natriuretic response to saline in conscious rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider