Why the study?
Is the -866G>A polymorphism in UCP2 associated with an increased risk of ischemic stroke in Chinese type 2 diabetic patients?
Population
844 Chinese type 2 diabetic patients (404 cases with ischemic stroke, 440 cases without ischemic stroke)
Comparison
-866G>A polymorphism in UCP2 (A allele) vs Absence of the A allele / other genotypes
Design
Case-control
Follow-up
4 years
Authors
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Variant associated with stroke in Chinese diabetic women; hypothesis-generating and requires validation before any clinical use.
Is the -866G>A polymorphism in UCP2 associated with an increased risk of ischemic stroke in Chinese type 2 diabetic patients?
The A allele of the -866G>A variant of UCP2 is associated with an increased risk of ischemic stroke in Chinese women with type 2 diabetes.
Chai et al. (2012) studied this question.
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