January 12, 2008DiabetesOpen Access

The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men

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Why the study?

Does the A allele of the -866G>A variant of UCP2 reduce the risk of coronary artery disease in men with type 2 diabetes?

Structured PICO

Does the A allele of the -866G>A variant of UCP2 reduce the risk of coronary artery disease in men with type 2 diabetes?

Population

3,122 subjects with type 2 diabetes, hypertension, and microalbuminuria from the 6-year prospective DIABHYCAR Study, plus an independent hospital-based cohort of 335 men (52% with CAD).

Intervention

Presence of the A allele of the -866G>A variant in the UCP2 promoter

Comparator

Absence of the A allele (G allele carriers)

Outcome

Incident cases of coronary artery disease (CAD)hard clinical

The A allele of the UCP2 -866G>A variant is associated with a decreased risk of coronary artery disease in men with type 2 diabetes.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support genetic testing for CAD risk in type 2 diabetes; leaves open replication and causal validation in prospective studies.

Cite This Study

Cheurfa et al. (2008) studied this question.

synapsesocial.com/papers/6a1fec8991899344c12e5825 https://doi.org/10.2337/db07-1292

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The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men

Structured PICO

Discussion

Implication

Cite This Study

The Common −866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider