Why the study?
Does the UCP2-866G>A variant increase oxidative stress and CHD risk in men?
Population
465 diabetic men (mean age 61.7 +/- 13.3 years) and 2695 healthy men (mean age 56.1 +/- 3.5 years)
Comparison
UCP2-866A allele (AA genotype) vs UCP2-866G allele (GG genotype)
Design
Cohort
Follow-up
median 10.2 years (for healthy men cohort)
Authors
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Should not yet alter CHD risk assessment in men; leaves open UCP2 variant utility pending prospective validation.
Does the UCP2-866G>A variant increase oxidative stress and CHD risk in men?
The UCP2-866A allele is associated with increased oxidative stress in diabetic men and a doubled risk of CHD in healthy men, providing in vivo evidence of UCP2's role in modifying CHD risk.
S Dhamrait (2004) studied this question.
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