Population
Zebrafish cardiovascular mutant dococs226 (dco) and Cx46lacZ/lacZ null mice
Comparison
Genetic mutation or knockdown of Gja3/Cx46 vs Wild-type (WT) siblings/littermates
Design
Preclinical
Follow-up
Up to 72 hours postfertilization and postnatal day 3
Authors
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Caution against clinical translation from animal models; leaves open Cx46's role in human conduction disease and cardiomyopathy.
In vivo studies in zebrafish and mice demonstrate that cardiac electrical forces, mediated by Cx46, are required to preserve cardiac chamber morphology and coordinate ventricular conduction.
Bussen et al. (2010) studied this question.
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