September 1, 1991Circulation Research

Influence of electrical axis of stimulation on excitation of cardiac muscle cells.

View Full Paper

Ask AI

Bookmark

Population

Single frog and guinea pig ventricular myocytes (n=30 frog, n=23 guinea pig for 2-msec pulses)

Comparison

Extracellular field stimulation with rectangular… vs Extracellular field stimulation with rectangular…

Design

Preclinical

Authors

LTLeslie TungElectrophysiology NSN SlizJohns Hopkins University MMM.R. MulliganJohns Hopkins University

Discussion

Member takes

Implication

May inform defibrillation vector optimization; leaves open translation beyond isolated myocytes.

Structured PICO

Population

Single frog and guinea pig ventricular myocytes (n=30 frog, n=23 guinea pig for 2-msec pulses)

Intervention

Extracellular field stimulation with rectangular pulses oriented parallel to the long axis of the cell

Comparator

Extracellular field stimulation with rectangular pulses oriented perpendicular to the long axis of the cell

Outcome

Excitation field strengthsurrogate

Cardiac myocytes are significantly more excitable when the stimulating electric field is parallel to their long axis, providing a cellular basis for the greater efficacy of orthogonal sequential shocks in defibrillation.

Cite This Study

Tung et al. (1991) studied this question.

synapsesocial.com/papers/6a925cf91b6b183c406c5aa5 https://doi.org/10.1161/01.res.69.3.722

View Full Paper

Ask AI

Bookmark

Influence of electrical axis of stimulation on excitation of cardiac muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of electrical axis of stimulation on excitation of cardiac muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider