Why the study?
Does clonidine hydrochloride improve blood pressure in patients with moderately severe hypertension?
Does clonidine hydrochloride improve blood pressure in patients with moderately severe hypertension?
Clonidine is an effective centrally-acting antihypertensive when combined with a diuretic, comparable to methyldopa but with a higher frequency of side effects and risk of rebound hypertension upon rapid withdrawal.
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Supports clonidine as alternative in diuretic-treated hypertension; leaves open agent selection by side-effect tolerance.
Mary Ellen Kosman (1975) studied this question.
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