Why the study?
Does clonidine reduce blood pressure in patients with moderate or severe hypertension?
Does clonidine reduce blood pressure in patients with moderate or severe hypertension?
Clonidine is a highly effective, low-dose antihypertensive agent for moderate to severe hypertension with a favorable orthostatic side effect profile compared to older agents.
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Supports clonidine consideration in moderate-severe hypertension with fewer orthostatic effects; leaves open modern RCTs versus contemporary agents.
William A. Pettinger (1975) studied this question.
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