April 28, 1973BMJOpen Access

Effects of Clonidine Withdrawal: Possible Mechanisms and Suggestions for Management

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Why the study?

Does intravenous phentolamine and propranolol improve blood pressure and symptoms in patients experiencing clonidine withdrawal?

Population

n=5 patients who had previously ceased clonidine and experienced severe rebound rise in blood pressure with…

Design

Case_series

Authors

SHStephen N. HunyorNorthern Sydney Local Health District LHL. HanssonSahlgrenska University Hospital THTimothy S. HarrisonAga Khan University

Discussion

Member takes

Implication

Supports combined alpha-beta blockade for clonidine withdrawal; hypothesis-generating case report requiring prospective validation.

Structured PICO

Does intravenous phentolamine and propranolol improve blood pressure and symptoms in patients experiencing clonidine withdrawal?

Population

n=5 patients who had previously ceased clonidine and experienced severe rebound rise in blood pressure with agitation and insomnia

Intervention

Intravenous phentolamine and propranolol (alpha and beta adrenergic receptor blockade)

Outcome

Control of blood pressure and alleviation of symptoms (agitation and insomnia)

Rebound hypertension and symptoms from clonidine withdrawal are associated with increased catecholamines and can be promptly treated with combined alpha and beta blockade.

Cite This Study

Hunyor et al. (1973) studied this question.

synapsesocial.com/papers/69d71b268a0e2c5879bef17a https://doi.org/10.1136/bmj.2.5860.209

Topics

Hypertension management

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Effects of Clonidine Withdrawal: Possible Mechanisms and Suggestions for Management

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of Clonidine Withdrawal: Possible Mechanisms and Suggestions for Management

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider